LONDON, 09 June 2023: Arix Bioscience plc (“Arix” or the “Company”) (LSE: ARIX), a transatlantic venture capital company focused on investing in breakthrough biotechnology companies, notes that its portfolio company, Disc Medicine, today announced preliminary findings from its Phase 2 open-label BEACON trial evaluating bitopertin, an orally administered glycine transporter 1 (GlyT1) inhibitor, in patients with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) at the European Haematology Association (EHA) 2023 Congress in Frankfurt, Germany.

The initial trial data from the BEACON study demonstrated consistent decreases in protoporphyrin IX (the disease-causing metabolite in EPP), significant increases in reported sunlight tolerance and improvements in measures of patient quality of life.

The BEACON trial is a randomised, open-label, parallel-arm trial enrolling up to 22 patients with EPP or XLP at trial sites in Australia. This trial was designed to assess changes in levels of PPIX, as well as measures of photosensitivity, quality of life, and safety and tolerability.

“We are very encouraged by the positive data from the BEACON trial. This is an important clinical milestone for the company and a major development for patients who suffer from erythropoietic protoporphyria. We look forward to supporting Disc Medicine as they continue to advance the BEACON study through clinical development. We are also thrilled that Disc are achieving these important clinical milestones less than two years after our initial investment, demonstrating a success of our strategy in action.”

Robert Lyne, CEO of Arix Bioscience